Recently, the role of Nucleotide-binding oligomerization domain (NACHT), Leucine-rich repeat (LRR), and Pyrin domation (PYD) domains-containing protein 3 (NLRP3) inflammasome-dependent IL-1β has emerged as a novel contributor to depressive disorders (Alcocer-Gomez and Cordero, 2014; Kaufmann et al., 2017). Here, NLRP3 is linked to depressive disorder.