This survey reveals that selenite/sodium selenite induced cataracts was the preferred model in studies with natural products used against cataract, followed by sugar-induced lens opacity/diabetes induced cataract models, AGE- BSA cross-linking inhibition assay, lens aldose reductase activity models, and hydrogen peroxide-induced cataract, and other miscellaneous models. This evidence concerns the gene AKR1B1 and cataract.