GLP1R and Parkinson disease: Soon after, Yun et al. demonstrated that, by preventing microglial activation through administration of a glucagon-like peptide-1 receptor (GLP1R) agonist, they were able to hinder astroglial transition toward an A1 phenotype, and this resulted in neuroprotection and preservation of motor functions in two mouse models of PD (Yun et al., 2018).