PPARG and Alzheimer disease: Reports that Pio and other TZD improve cognitive performance in AD patients and in mouse models of the disease (Risner et al., 2006; Hanyu et al., 2010; Mandrekar-Colucci et al., 2012; Searcy et al., 2012; Ahmadian et al., 2013) suggest that PPARγ may be potential therapeutic targets in AD (Zolezzi et al., 2017).