While the link between T2D and AD may be equivocal (see Vemuri et al., 2017) and awaits longitudinal studies in humans that use new imaging technologies such as positron emission tomography (PET; see Arnold et al., 2018), evidence exists for an association between perturbed insulin signaling and AD histopathology, namely, Aβ aggregates and Tau protein-containing neurofibrillary tangles (NFT) (de la Monte and Tong, 2014; Mullins et al., 2017; Arnold et al., 2018). This evidence concerns the gene INS and Alzheimer disease.