MAPT and Alzheimer disease: The latter observation, which is consistent with a previous report that TZD reduce Tau hyperphosphorylation in a 3 × Tg mouse model of AD (Yu et al., 2015), is important since Tau is now recognized as a critical mediator of the synaptotoxic effects of Aβ (Kimura et al., 2007; Roberson et al., 2007; Ittner et al., 2010; Lopes et al., 2016).