Notably, some authors have also attributed the neuroprotective effects of TZD to their anti-inflammatory and/or -oxidative properties (Heneka et al., 2005, 2015; Wang X.K. et al., 2017; Zhang et al., 2017), phenomena that could help explain the purported role of activated PPARγ in a spectrum of neurological diseases (Zolezzi et al., 2017). The gene discussed is PPARG; the disease is nervous system disorder.