Mice lacking CX3CR1 develop increased disease severity in animal models of experimental autoimmune encephalomyelitis (EAE), low-endotoxemia, Parkinson’s disease, Amyotrophic lateral sclerosis, and Diabetic retinopathy (Cardona et al., 2006, 2015; Mendiola et al., 2017). The gene discussed is CX3CR1; the disease is amyotrophic lateral sclerosis.