SMAD7 and neoplasm: miR-92a has been shown to disrupt the expression of several tumour suppressors such as PTEN57,58, Dickkopf WNT Signalling Pathway Inhibitor 3 (DKK3)57, Kruppel-like factor 4 (KLF4)59 and mothers against decapentaplegic homolog 7 (SMAD7)60.