On the other hand, previous research into colon cancer reported that the overexpression of mitotic arrest deficient 2‐like protein 2 (MAD2L2), a cancer suppressor protein that can inhibit CRC cell proliferation, migration and the ability of cells to form clones by triggering the degradation of nuclear receptor coactivator 3 (NCOA3)12. Here, MAD2L2 is linked to malignant colon neoplasm.