Both BIN1 AD risk alleles rs6431223 (OR = 1.12, P = 2.5 × 10−11) and rs6733839 (OR = 1.22, P = 7 × 10−44)22 were significantly associated with increased levels of CSF pTau181 (B = 0.21, P = 0.02 and B = 0.17 P = 0.04), but were not correlated with amyloid deposition as monitored with PET imaging (Table 1). The gene discussed is BIN1; the disease is Alzheimer disease.