MAPT and Alzheimer disease: In microglia from males, the loss of Bin1 results in downregulation of genes, encoding chaperone proteins, such as Hsc70, Hsp90aa1, Hsp90ab1, Dnaja1 and Dnajb1. Hsc70 expression is increased in AD model mice and patient brains63, and its inhibition promotes Tau degradation64.