Furthermore, we found a negative correlation between plasma levels of HDL cholesterol and sCD25 (r = −0.59, p < 0.001) and CRP (r = −0.24, p = 0.018) (Fig. 2a,b), but not with LPS (r = −0.08, p = 0.407) or sCD14 (r = −0.16, p = 0.119) in CVID patients. The gene discussed is CRP; the disease is common variable immunodeficiency.