ABCA1 and common variable immunodeficiency: Whereas there was no difference in cholesterol loading between macrophages from CVID patients and controls (data not shown), macrophages from CVID patients had significantly reduced cholesterol efflux capacity as compared to macrophages from healthy controls (14.6% [12.2%, 18.2%] vs 16.3% [13.0%, 21.3%], p = 0.04, results given as median [25% percentile, 75% percentile]) (Fig. 6), consistent with our findings of low ABCA1 expression in CVID patients.