To understand the pathophysiological role of APIP in the heart under oxygen availability, we first investigated the expression levels of APIP in cardiac tissues prepared from 18 patients with ischemic heart disease (IHD), congestive heart failure (CHF), dilated cardiomyopathy (DCM), or heart failure (HF) and 29 healthy adults (Supplementary Table 1). This evidence concerns the gene APIP and heart failure.