To examine the role of Ezh2 methyltransferase activity in ErbB2-driven mammary tumor progression, we treated 10 week-old MMTV-NIC mice with the Ezh2 inhibitor GSK126, which competes with S-adenosylmethionine (SAM) for binding to the EZH2 SET domain52. The gene discussed is ERBB2; the disease is breast cancer.