Strikingly, phosphorylation of the central energy sensor 5′ adenosine monophosphate-activated protein kinase (AMPK) and of its substrate acetyl-CoA carboxylase (ACC) were elevated in c-Src-deficient, as compared to c-Src-positive, tumor tissue and cell lines (Fig. 5a, b), correlating with an increased AMP:ATP ratio in c-Src-deficient cells (Fig. 5c, Supplementary Fig. 6b). Here, PRKAA1 is linked to neoplasm.