Linking this metabolic remodeling to PRC2 component mRNA translation, analysis of human breast cancer cell translatomes27 showed that the biguanide metformin, similarly to allosteric (rapamycin) or active site-directed (PP242) mTOR inhibitors, reduced the translational efficiency of EZH2 mRNA (Supplementary Fig. 7e). This evidence concerns the gene MTOR and breast carcinoma.