Similar results have revealed a higher susceptibility to Candida and Aspergillus infection in the absence of Toll IL1R8 (TIR8), a negative regulator of Th17 responses.33 The overgrowth of native Candida and Aspergillus species may be positively correlated with OLP severity, suggesting a disease link. The gene discussed is SIGIRR; the disease is oral lichen planus.