A previous study found that Ad-TERTp-E1A-1504 has no harmful effects on normal cells but inhibits and kills TERT- and EphA3-positive tumor cells, which is mediated through the protein kinase B/mammalian target of rapamycin (AKT/mTOR) signaling pathway via autophagy induction [17]. This evidence concerns the gene AKT1 and neoplasm.