We have previously shown that OV-induced type I IFN-α can increase the anti-tumor properties of NK cells [7], therefore given that CVA21 stimulated IFN-α in vitro (Fig. 2a), and activated NK cells in vivo (Fig. 1d), we examined the ability of OV-activated NK cells to eradicate CVA21-sensitive and CVA21-resistant cells. Here, IFNA1 is linked to neoplasm.