Co-treatment of NSCLC cells with LiCl or SB415286, which block the activity of GSK3β, partially restored cyclin D1 and cyclin D3 expression in BEZ235-treated NSCLC cells as well, except cyclin D1 in CL141 co-treated with LiCl (Fig. 3b). This evidence concerns the gene CCND1 and non-small cell lung carcinoma.