These EGFR-TKIs, such as gefitinib and erlotinib, have proven to be effective in non-small cell lung cancer (NSCLC) patients carrying specific activating mutations in the tyrosine kinase domain of EGFR, mostly within exon 18–21, such as the L858R point mutation and deletions in exon 19 [4–6]. Here, EGFR is linked to non-small cell lung carcinoma.