Here, we investigated the antitumor effects of dual PI3K/mTOR inhibition by BEZ235 as a monotherapy or in combination with cisplatin or BIBW2992 (afatinib), a second generation EGFR-TKI, in NSCLC cells with different EGFR status or sensitivity to EGFR-TKIs. Here, PIK3CA is linked to non-small cell lung carcinoma.