Consistent with a series of our studies, Connelly et al. showed that oral administration of a dual SGLT1/2-inhibitor led to an impaired cardiac function after myocardial infarction in a rat model with left anterior descending coronary artery ligation, while a selective SGLT2-inhibitor had no significant effect on this condition [38]. Here, SLC5A2 is linked to myocardial infarction.