HPGDS and cancer: Additionally, polyphenols have a selective effect on cancer cells because they exhibit a reduced regulation of the cellular machinery and, therefore, are more sensitive to the induction of quiescence and apoptosis, while normal cells can activate endogenous antioxidant mechanisms (e.g., glutathione S-transferase, γ-glutamyltransferase, and superoxide dismutase) to prevent cell death by DNA damage or lipid peroxidation [57, 58].