EGFR and neoplasm: Lucky et al. developed up-conversion nanoparticles (UCN) loaded with PEGylated titanium dioxide (TiO2) to increase tissue penetration using NIR; these nanoparticles were used for targeting EGFRs on the surface of cancer cells using anti-EGFR-antibody conjugated with PEGylated TiO2-UCNs to inhibit tumor proliferation, invasion, angiogenesis, and metastasis.