TLR1 and hydrops fetalis: Perinatal HF diet also produces methylation differences in the energy homeostasis gene, peroxisome proliferator-activated receptor α (Ppara) [6], the inflammatory genes, toll-like receptors 1 and 2 (Tlr-1 and Tlr-2) [7], and the hepatic cell cycle inhibitor, cyclin-dependent kinase inhibitor (Cdkn1a) [8].