Among the differentially methylated genes, diacylglycerol kinase gamma (Dgkg), inositol-triphosphate 3-kinase (Ip3k), inositol polyphosphate-5-phosphatase (Inpp5), PI3 kinase (Pi3kc2b), phosphodiesterase 3 (Pde3), Cbl proto-oncogene (Cbl), and leukocyte antigen-related protein tyrosine phosphatase (Lar), were up-regulated in PHF rats, while pyruvate kinase (Pklr) was up-regulated in the MHF group (Figure 5c). The gene discussed is ITPKB; the disease is Marburg hemorrhagic fever.