In addition, we showed that BECN1 expression, a key pathogenic factor for the pathogenesis of neurodegenerative diseases including Alzheimer’s disease, is elevated, and the overexpression of BECN1 has been found to reduce disease pathogenesis through the autophagy-mediated clearance of the toxic amyloid precursor [33]. This evidence concerns the gene BECN1 and early-onset autosomal dominant Alzheimer disease.