Boffa et al. reported that NSCLC patients with >1.1 PD-L1+ CTCs/mL of blood at diagnosis had worse two-year survival compared with those with ≤1.1 PD-L1+ CTCs/mL (31.2% vs. 78.8%, p = 0.002). This evidence concerns the gene CD274 and non-small cell lung carcinoma.