SIK1 and acute kidney injury: From our knowledge of the SIK1 network [12], such acute increases in Na+in rapidly activate the basolateral SIK1s, which are part of the Na,K-ATPase complex, and thereby initiate the events in the SIK1 network which counteract the tendency for Na+ reabsorption to decline during AKI (by increasing the quantity of basolateral Na,K-ATPases).