Some T helper 1 (Th1) cytokines (e.g., IFN-γ, lymphotoxin, and TNF) have been implicated in driving the immunopathological process leading to cerebral malaria, whereas some Th2 (e.g., IL-10, transforming growth factor (TGF)-β) cytokines appear to inhibit this process [32]. The gene discussed is TNF; the disease is cerebral malaria.