GSK3B and malignant colon neoplasm: Our previous studies showed that natural compounds can inhibit cancer cell proliferation and migration [24]; for example, thymoquinone was shown to inhibit the migration of colon cancer by suppressing prostaglandin E2-induced COX-2 activation [25], taiwanin E was found to suppress colon cancer cell migration via the p38 Mitogen-activated protein kinase (MAPK) pathway to reduce MMP-2/9 expression [26], and taiwanin C was found to inhibit oral cancer cell migration via GSK-3β activation to reduce β-catenin expression [27].