OMD of KRAS, NRAS, BRAF and TP53 mutations in matched BM and PL from 76 MM patients indicated that RR patients (n = 52) had significantly more mutations in the plasma (PL) than ND patients (n = 24) (p = 0.0002, Chi-square test, data not shown). This evidence concerns the gene BRAF and Miyoshi myopathy.