These reactions include food protein-induced enterocolitis syndrome, cow’s milk protein-induced enteropathy, and cow’s milk-induced proctitis and proctocolitis [2], and also conditions where milk protein-specific IgE antibodies are present may occur, like in eosinophilic esophagitis or gastroesophageal reflux disease. The gene discussed is IGHE; the disease is gastroesophageal reflux disease.