CD8A and neoplasm: IR also induces the production of IFN (type I) by activating a stimulator of interferon genes (STING) pathway in tumor-infiltrating DCs, as well as the increased secretion of CXCL10, a C-X-C chemokine receptor (CXCR3+) that recruits IFN-γ secreting CD8+ T cells [34,75].