INS and Insulin resistance: Previous studies showed that myo-inositol regulates glucose metabolism and transport [29], moreover, Shorkpour et al., showed that Myo-inositol supplementation in women with polycystic ovary syndrome, compared with metformin, significantly reduced fasting plasma glucose, serum insulin levels, homeostasis model of assessment-insulin resistance, serum triglycerides, and significantly increased the quantitative insulin sensitivity check index compared with metformin [30].