Further, NFBTA down-regulation of phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) genes augments its anti-glioblastoma efficacy, since knockout or silencing of PIK3R1 genes evokes the responses of decreased proliferation, migration, and invasion in 081,110, and 081,024 GBM cell lines [63]. This evidence concerns the gene PIK3R1 and glioblastoma.