PD-L1 is also expressed by macrophages in the DLBCL TME and the infiltration of PD-1+ lymphocytes was associated with a superior survival in a cohort of patients receiving standard chemo-immunotherapy treatment (R-CHOP; rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) [39]. Here, CD274 is linked to diffuse large B-cell lymphoma.