This is consistent with the hypothesis that antipsychotics induce gene transcriptional changes and long-term effects through D2R-Gi/o signaling disruption [36,101], whereas D2R-βarr2 blockade mediates non-transcriptional changes that lead to the improvement in the positive symptoms of schizophrenia [4,45,101]. This evidence concerns the gene ARRB2 and schizophrenia.