CASP3 and Familial prostate cancer: Achillea teretifolia methanol extracts exhibited a remarkable cytotoxic effect on DU145 and PC-3 cells as time and concentration increased, with up-regulation of the mRNA expression level of the pro-apoptotic (bax, caspase-3) and anti-apoptotic (bcl-2), and down-regulation of the expression of bcl-2, and might contain anticancer compounds, activating the cytotoxicity and the apoptosis on prostate cancer cells [112].