A phenol from the root bark of Paeonia moutan and the grass of radix Cynanchi Paniculati, paeonol, has been reported to block growth of prostate cancer cells, DU145 and PC-3 in dose-and time-dependent manner, induce apoptosis and enhance activities of caspase-3, caspase-8, and caspase-9, reduced expression of Bcl-2, and rise expression of Bax, cut phosphorylated status of Akt and mTOR in DU145. This evidence concerns the gene CASP3 and Familial prostate cancer.