On the other hand, PSA is not entirely specific for prostate cancer, and other conditions, such as prostatitis, urinary tract infection (UTI), older age, benign prostate hyperplasia (BPH) and bicycle riding can cause elevations in PSA levels, and some medications, like 5α-reductase inhibitors, aspirin, thiazide and statins cause decreases in PSA levels [13,36]. This evidence concerns the gene KLK3 and male reproductive organ cancer.