CASP9 and Familial prostate cancer: Saffron extract (SE) showed dose and time-dependent antiproliferative effect on 5 different malignant prostate cancer cell lines (IC50 = 0.4–4 mg/mL), by arresting cells at G0/G1 phase and caused apoptosis through strikingly downregulation of Bcl-2 expression, activation of caspase-9 [132].