In another study involving healthy individuals, CCR5-tropic HIV infection levels in Langerhans cells (LCs) ex vivo were also associated with the CCR5 genotype [6]: LCs isolated from individuals, who were genotypically −2459G/A and ORF wt/∆32, were markedly less susceptible to HIV than LCs from individuals who were genotypically −2459A/A and ORF wt/∆32. Here, CCR5 is linked to HIV infectious disease.