Tenascin-C, which belongs to the matricellular family of proteins, is poorly expressed in normal adult tissues but highly expressed in both tumor cells and tumor associated-stromal cells of many malignant tumors, such as glioma and breast and lung cancers, and its expression levels are associated with a poor prognosis in patients with these tumors [1,2,3,4]. The gene discussed is TNC; the disease is neoplasm.