NPPB and hydrops fetalis: In a calsequestrin female transgenic (CSQ-Tg, C57BL/6 x DBA/2 hybrid) mouse model of severe symptomatic HF with high mortality, oral daily TAK-272 in a dose-dependent fashion prolonged the survival and, at the highest dose (300 mg/kg), showed a significant reduction in elevated PRA, decreased cardiac hypertrophy, a two-fold increase in left ventricular EF, decreased plasma NT-proBNP levels, and decreased lung congestion—clearly signifying cardioprotection during HF [207].