Signaling molecules that are secreted via the non-classical pathway include: fibroblast growth factor-2 (FGF-2), an angiogenesis stimulant essential for tumor growth and metastasis [3]; galectin-1, an inducer for tumor-mediated immune suppression [4]; and cytokine interleukin-1β (IL-1 β) from activated macrophages, a mediator of the inflammatory response involved in cell proliferation, differentiation, and apoptosis [5]. Here, FGF2 is linked to neoplasm.