Together, these results confirm that WNT11 mRNA is increased in CRC, identify associations of WNT11 expression and the expression of three potential Wnt-11 receptors and provide further evidence that increased expression of WNT11, in combination with FZD6, RYK, and/or PTK7, could be an indicator of poor prognosis. The gene discussed is RYK; the disease is colorectal carcinoma.