However, FZD7 gene silencing also reduces Wnt-β-catenin signaling [10] and FZD7 is also a receptor for Wnt-3A [11,12], which increases CRC cell proliferation [13], and for Wnt-2B, which drives the mesenchymal to epithelial transition (MET) [14]. The gene discussed is FZD7; the disease is colorectal carcinoma.