NOTCH3 and ovarian carcinoma: Interestingly, the expression of the Notch3 intracellular domain can enhance the expression of various embryonic stem cell markers, including Oct4, Nanog, Klf4, Rex1, Rif1, Sall4, and NAC1, as well as the ATP-binding cassette sub-family B member 1 (ABCB1), and can thereby regulate the development of resistance to carboplatin in ovarian cancer cells [50].