Furthermore, the authors revealed functional roles for several stem cell-related signaling pathways, such as TGF-β co-receptor endoglin and the hedgehog transcriptional mediator Gli2, in regulating chemotherapy resistance in ovarian cancer stem cells [40], thus raising the possibility that novel therapeutic strategies targeting these pathways in metastasized ovarian cancer stem cells would be attractive approaches to overcome chemotherapy resistance. This evidence concerns the gene ENG and ovarian carcinoma.