CCNE2 and neoplasm: For example, one of the microarray expression studies, which is included in the present meta-analysis, demonstrated, by comparing the polysome-associated with the cytoplasmic RNA fraction, that the antiproliferative effect of MTF is mainly a result of translational suppression of mRNAs of cell cycle regulators and tumor promoters, including cyclin E2 (CCNE2) and ornithine decarboxylase 1 (ODC1), that are regulated via the mTORC1/eukaryotic translation initiation factor 4E-binding (4EBP) protein pathway [14].