CD274 and intrahepatic cholangiocarcinoma: Another PD-L1 inhibitor discussed here, atezolizumab, was most famous for its IMvigor211 phase III trial [107], in which 931 patients with metastatic UC treated after platinum-based chemotherapy were randomly treated with either atezolizumab (1200 mg every three weeks) or ICC (between vinflunine, paclitaxel, or docetaxel).