LACTB and sinusitis: Amoxicillin–clavulanate is indicated for the treatment of lower respiratory tract infections, acute bacterial otitis media, and sinusitis caused by beta-lactamase-producing H. influenzae and M. catarrhalis; skin and skin structure infections caused by beta-lactamase-producing S. aureus, E. coli, and Klebsiella spp.; and urinary tract infections caused by beta-lactamase-producing E. coli, Klebsiella spp., and Enterobacter spp.