Early increases in VEGFA and CXCL8 gene expression as well as the down-regulation of VCL mRNA and the reduced E-cadherin protein indicate a change to a more invasive function of the MCF-7 cells exposed to short-term microgravity which supports earlier data with thyroid cancer cells exposed to parabolic flight maneuvers [16]. This evidence concerns the gene CXCL8 and thyroid gland carcinoma.