ERBB2 and breast cancer: As full-length ERBB2 and the d16HER2 splice variant are coexpressed in human HER2-positive BC, Palladini and colleagues studied their interaction and response to targeted therapy in hybrid transgenic mice that express full-length human ERBB2 and d16HER2 (F1 HER2/Delta16), compared with parental HER2 and d16HER2 [40].