Several studies have reported that the concentrations of TIMP-2 and IGFBP7 proteins in urine are early indicators of AKI in critically ill patients.[13–17] However, these studies differed markedly, including in their urinary TIMP-2 and IGFBP7 threshold concentrations, making the urinary TIMP-2 and IGFBP7 levels more reliably associated with AKI unclear. This evidence concerns the gene TIMP2 and acute kidney injury.