When the pre-test probability of 20% was combined with the PLR and NLR, the post-test probabilities of urinary TIMP-2 and IGFBP7 ≥0.3 (ng/mL)2/1000 and <0.3 (ng/mL)2/1000 for AKI were 30% and 5%, respectively (Fig. 6A). The gene discussed is IGFBP7; the disease is acute kidney injury.