In monocytes/macrophages, mTOR restricts proinflammatory and promotes anti-inflammatory responses.[33] MiR-208 may activate Wnt/β-catenin signaling pathway through targeting Nemo-like kinase (NLK), a Wnt/β-catenin signaling inhibitor.[34] In IBD, Wnt/β-catenin signaling has a multifunctional role in epithelial stem cell identity, proliferation, and epithelial homeostasis regulation.[35] Thus, we conceive that circ_004662 may act as miRNA sponges and be involved in the pathogenesis of CD. This evidence concerns the gene NLK and Cowden disease.