TARDBP and amyotrophic lateral sclerosis: Similarly, while cytoplasmic TDP-43 inclusions are a hallmark of amyotrophic lateral sclerosis (ALS), and rare pathogenic variants in the TARDBP gene have been linked to ALS (19–21), to date, no large GWAS or meta-analysis of ALS GWAS has detected a signal near the TARDBP gene (22, 23).