Similarly, a high allergen-specific IgE levels predicted childhood-onset atopic eczema, but there was little evidence for an association between the allergen-specific IgE and adult-onset disease (OR, 1.90 [95% CI, 1.32-2.74] and 0.86 [95% CI, 0.54-1.36], respectively; Table III). The gene discussed is IGHE; the disease is atopic eczema.