DDR1 and urinary tract obstruction: DDR1 has also been shown to play prominent roles in a number of kidney disease that include mouse models of Alports[12, 13], obstructive uropathy[14], the remnant kidney model of chronic kidney disease[15] and nephrotoxic serum nephritis[16] [17]. Thus, based on these findings we entertained the possibility that DDR1 would play a prominent role in PKD pathogenesis and provide a link between the extracellular matrix and regulation of growth of cyst lining epithelia.