These include kidney injury molecule-1 (uKIM-1), albumin (uAlb), total protein, beta2-microglobulin (uβ2M), cystatin C (uCysC), clusterin (uClu), trefoil factor-3 (uTFF3), N-acetyl-β-D-glucosaminidase (uNAG), neutrophil gelatinase-associated lipocalin (uNGAL), osteopontin (uOPN) and interleukin-18 (IL-18).[15–17] Recent studies of AKI in poisoned patients have demonstrated the usefulness of these biomarkers, including in glyphosate [18–19] and paraquat poisoning, [20,21] in animals and humans. The gene discussed is SPP1; the disease is acute kidney injury.