To elucidate the underlying mechanisms for the metabolic alterations in the Hipk tumors, we examined gene expression of dMyc and Sima (HIF1-α in vertebrates) since these two transcription factors are well-known inducers of glycolysis in cancer cells (Miller et al., 2012a; Marín-Hernández et al., 2009). The gene discussed is HIF1A; the disease is cancer.